Polysaccharides from Tetrastigma hemsleyanum Diels et Gilg: Extraction optimization, structural characterizations, antioxidant and antihyperlipidemic activities in hyperlipidemic mice

Published on Mar 1, 2019in International Journal of Biological Macromolecules4.78
· DOI :10.1016/j.ijbiomac.2018.11.236
Yi Ru1
Estimated H-index: 1
(FZU: Fuzhou University),
Xiao Chen1
Estimated H-index: 1
(FZU: Fuzhou University)
+ 4 AuthorsBin Qiu35
Estimated H-index: 35
(FZU: Fuzhou University)
Abstract In this study, a novel polysaccharide TDGP-3 from Tetrastigma hemsleyanum Diels et Gilg was extracted by enzymolysis-ultrasonic assisted extraction (EUAE) method and its antioxidant and hypolipidemic activities were evaluated. With a molecular weight of 3.31 × 10 5  Da, TDGP-3 was composed of 1,4-Glcp, 1,4-Glap and 1,3,6-Manp linkage in the main chain. TDGP-3 showed potential effects on relieving hyperlipidemia and preventing oxidative stress, reflecting by regulating blood lipid levels (TC, TG, HDL-C and LDL-C), decreasing the contents of MDA in liver, restoring the activities of hepatic antioxidant enzymes (SOD, GSH-Px and CAT). The results clearly indicated that the TDGP-3 possesses a potent hypolipidemic activity and might be used for hyperlipidaemia treatment.
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