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AMPK: a therapeutic target of heart failure - not only metabolism regulation

Published on Jan 31, 2019in Bioscience Reports2.54
· DOI :10.1042/BSR20181767
Xuan Li2
Estimated H-index: 2
(UMMC: University of Mississippi Medical Center),
Jia Liu2
Estimated H-index: 2
(UMMC: University of Mississippi Medical Center)
+ 5 AuthorsJi Li6
Estimated H-index: 6
(UMMC: University of Mississippi Medical Center)
Abstract
Heart failure (HF) is a serious disease with high mortality. The incidence of this disease has continued to increase over the past decade. All cardiovascular diseases causing dysfunction of various physiological processes can result in HF. AMP-activated protein kinase (AMPK), an energy sensor, has pleiotropic cardioprotective effects and plays a critical role in the progression of HF. In this review, we highlight that AMPK can not only improve the energy supply in the failing heart by promoting ATP production, but can also regulate several important physiological processes to restore heart function. In addition, we discuss some aspects of some potential clinical drugs which have effects on AMPK activation and may have value in treating HF. More studies, especially clinical trials, should be done to evaluate manipulation of AMPK activation as a potential means of treating HF.
  • References (125)
  • Citations (2)
References125
Newest
#1Xuan Li (UMMC: University of Mississippi Medical Center)H-Index: 2
#2Jia Liu (UMMC: University of Mississippi Medical Center)H-Index: 2
Last.Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 6
view all 9 authors...
#1Xu Chen (UMMC: University of Mississippi Medical Center)H-Index: 5
#2Xuan Li (UMMC: University of Mississippi Medical Center)H-Index: 2
Last.Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 6
view all 10 authors...
#1Lin Wang (UMMC: University of Mississippi Medical Center)H-Index: 5
#2Nanhu Quan (UMMC: University of Mississippi Medical Center)H-Index: 5
Last.Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 6
view all 9 authors...
#1Yenan Feng (PKU: Peking University)H-Index: 4
#2Zhang Y (PKU: Peking University)H-Index: 31
Last.Han Xiao (PKU: Peking University)H-Index: 2
view all 3 authors...
#1Fang Han (WMU: Weifang Medical University)H-Index: 9
#2Kai Li (WMU: Weifang Medical University)H-Index: 1
Last.Xiaodong Sun (WMU: Weifang Medical University)H-Index: 8
view all 7 authors...
#1Jie Zhang (UMMC: University of Mississippi Medical Center)H-Index: 1
#2Peng Zhao (SDU: Shandong University)H-Index: 1
Last.Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 6
view all 8 authors...
#1Nanhu Quan (UMMC: University of Mississippi Medical Center)H-Index: 5
#2Wanqing Sun (UMMC: University of Mississippi Medical Center)H-Index: 5
Last.Ji Li (UMMC: University of Mississippi Medical Center)H-Index: 6
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