Dietary Methionine Restriction Upregulates Endogenous H₂S via miR‐328‐3p: A Potential Mechanism to Improve Liver Protein Metabolism Efficiency in a Mouse Model of High‐fat‐diet‐induced Obesity

Scope Dietary methionine restriction (MR) promotes multifaceted health benefits . Moreover, lower rate of protein synthesis by dietary MR is associated with life span extension. The goal of this work is to explore how dietary MR would affect protein metabolism in a mouse model of high‐fat‐diet‐induced obesity (DIO). Methods and results DIO mice (male C57BL/6) are subjected to dietary MR for 22 weeks. High‐throughput sequencing technology,...