Hypothalamic Obesity Treatment Demands Thinking Outside the Box

To the Editor It was no surprise to read about the disappointing treatment outcomes in Rose et al.’s study describing the self-report data from the International Registry of Hypothalamic Obesity Disorders (1). The poor outcomes and the lack of effective treatment options informed by randomized controlled trials (2) make the clinical management of hypothalamic obesity (HO) very challenging indeed. Besides the severe cardiometabolic morbidities...