New pharmacological effect of fulvestrant to prevent oxaliplatin‐induced neurodegeneration and mechanical allodynia in rats

Volume: 145, Issue: 8, Pages: 2107 - 2113
Published: Dec 19, 2018
Abstract
Oxaliplatin, which is widely used as chemotherapy for certain solid cancers, frequently causes peripheral neuropathy. Commonly described neuropathic symptoms include aberrant sensations such as mechanical allodynia (hypersensitivity to normally innocuous stimuli). Although oxaliplatin neuropathy is a dose-limiting toxicity, there are no established preventive strategies available at present. By screening several sets of small-molecule chemical...
Paper Details
Title
New pharmacological effect of fulvestrant to prevent oxaliplatin‐induced neurodegeneration and mechanical allodynia in rats
Published Date
Dec 19, 2018
Volume
145
Issue
8
Pages
2107 - 2113
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