Fundamental Roles of Axial Stretch in Isometric and Isobaric Evaluations of Vascular Contractility
Abstract
Vascular smooth muscle cells (VSMCs) can regulate arterial mechanics via contractile activity in response to changing mechanical and chemical signals. Contractility is traditionally evaluated via uniaxial isometric testing of isolated rings despite the in vivo environment being very different. Most blood vessels maintain a locally preferred value of in vivo axial stretch while subjected to changes in distending pressure, but both of these...
Paper Details
Title
Fundamental Roles of Axial Stretch in Isometric and Isobaric Evaluations of Vascular Contractility
Published Date
Jan 25, 2019
Volume
141
Issue
3
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