Analysis of discrete local variability and structural covariance in macromolecular assemblies using Cryo-EM and focused classification
Abstract
Single-particle electron cryo-microscopy and computational image classification can be used to analyze structural variability in macromolecules and their assemblies. In some cases, a particle may contain different regions that each display a range of distinct conformations. We have developed strategies, implemented within the Frealign and cisTEM image processing packages, to focus-classify on specific regions of a particle and detect potential...
Paper Details
Title
Analysis of discrete local variability and structural covariance in macromolecular assemblies using Cryo-EM and focused classification
Published Date
Aug 1, 2019
Journal
Volume
203
Pages
170 - 180
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