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Luteolin‐mediated Kim‐1/NF‐kB/Nrf2 signaling pathways protects sodium fluoride‐induced hypertension and cardiovascular complications

Published on Nov 1, 2018in Biofactors3.598
· DOI :10.1002/biof.1449
Ademola Adetokunbo Oyagbemi16
Estimated H-index: 16
(UI: University of Ibadan),
Temidayo Olutayo Omobowale10
Estimated H-index: 10
(UI: University of Ibadan)
+ 9 AuthorsMomoh A. Yakubu13
Estimated H-index: 13
(TSU: Texas Southern University)
Abstract
: The use of sodium fluoride (NaF) as a major ingredient for tooth paste, mouth wash, and mouth rinse has become inevitable in our day-to-day life. However, flavonoids such as Luteolin might be of great value in the prevention of toxicity associated with accidental or inevitable ingestion of NaF. In the study, 40 male Wistar albino rats were randomly divided into four groups with 10 rats in a group. Group A was the control group and received normal saline, Group B was exposed to NaF at 300 ppm (300 mg/L) in drinking water daily for a week, Groups C and D were exposed to 300 ppm (300 mg/L) of NaF and coadministered with Luteolin orally daily at a dosage of 100 mg/kg and 200 mg/kg for the same time point. Our results indicated that NaF caused significant increases in systolic blood pressure, diastolic blood pressure, mean arterial pressure, malondialdehyde, protein carbonyl, myeloperoxidase, advanced oxidative protein products, together with significant reductions in glutathione peroxidase, superoxide dismutase, catalase, glutathione reductase, reduced glutathione, and nitric oxide (NO) bioavailability. The electrocardiogram results showed that NaF alone caused significant prolongation of QT and QTc intervals. Immunohistochemistry revealed that NaF caused increase expressions of Kidney injury marker 1 (Kim-1), nuclear factor kappa bet (NF-κB), nuclear factor erythroid 2-related factors 2 (Nrf2), and cardiac troponin I (CTnI). Together, Luteolin coadministration with NaF improved NO bioavailability, reduced high blood pressure, markers of oxidative stress, reversed prolongation of QT and QTc intervals, and lowered the expressions of Kim-1, NF-κB, and CTnI. © 2018 BioFactors, 44(6):518-531, 2018.
  • References (67)
  • Citations (3)
References67
Newest
#1Sarawoot Bunbupha (MSU: Mahasarakham University)H-Index: 4
#2Chutamas Wunpathe (KKU: Khon Kaen University)H-Index: 3
Last. Poungrat Pakdeechote (KKU: Khon Kaen University)H-Index: 14
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Abstract Carthamus tinctorius L. (CT) is widely used in Asian countries as a beverage and in folk medicine. The effects of CT extract on hemodynamics, vascular remodeling, the renin-angiotensin system (RAS) and oxidative stress in the two-kidney, one clip (2K-1C) hypertensive rat model were investigated. Renovascular hypertension was induced in male Sprague-Dawley rats and were treated with CT extract (500 mg/kg/day) or captopril (5 mg/kg/day) or vehicle for four weeks. CT extract or captopril r...
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#1Nashwa Abu-Elsaad (Mansoura University)H-Index: 6
#2Amr El-Karef (Mansoura University)H-Index: 5
Luteolin is a major component of many medicinal plants and traditional medicines. The current study aims at testing its protective effect against high-carbohydrate/high-fat (HCHF) diet-induced cardiac dysfunction in rats. Male Wistar rats were divided into six groups as follows: control group that received standard rat chow, group received HCHF diet (~ 30% carbohydrate and 42% fat) daily for 16 weeks, and four groups received HCHF diet concurrently with luteolin (10, 25, 50 or 100 mg/kg; 10% w/v...
3 CitationsSource
#1Yichuan Fan (PRC: China Medical University (PRC))H-Index: 2
#2Xingzhi Zhao (PRC: China Medical University (PRC))H-Index: 2
Last. Xinhua Hu (PRC: China Medical University (PRC))H-Index: 1
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Abstract Background The prognostic value of cardiac troponin elevation in atrial fibrillation (AF) is unclear. Objective To investigate the association of cardiac troponin elevation with adverse outcomes in AF by conducting a meta-analysis. Methods We systematically searched the PubMed and Embase databases until April 2017 for studies assessing the association of cardiac troponin-T (cTnT) or troponin-I (cTnI) elevation with adverse outcomes in AF. The outcome measures were all-cause mortality an...
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#1Xiao Tan (NEAU: Northeast Agricultural University)H-Index: 6
#2Biying Liu (NEAU: Northeast Agricultural University)H-Index: 11
Last. Zhigang Zhang (NEAU: Northeast Agricultural University)H-Index: 16
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Abstract Luteolin (Lut) belongs to the flavonoid family with various beneficial bioactivities. Here, we investigated whether Lut attenuate mercuric chloride (HgCl 2 )-induced renal injury in rat. We found that oral gavage administration of Lut (80 mg/kg) alleviated anemia and renal histology upon HgCl 2 treatment (80 mg/L). Lut also significantly reduced HgCl 2 -induced oxidative stress and inflammatory, presenting as the reduced malondialdehyde (MDA) formation, increased glutathione (GSH) level...
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#1Cristian Palmiere (UNIL: University of Lausanne)H-Index: 21
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Abstract The possible use of biochemical markers in the postmortem diagnosis of myocardial ischemia is well known in the forensic setting, though several issues have limited its widespread adoption. The study presented herein focuses of N-terminal pro-B-type natriuretic peptide, troponin T, and troponin I, and the possible influence due to sampling site chosen, postmortem interval elapsed, and cardiopulmonary resuscitation attempts. Comparisons were performed between antemortem serum levels of t...
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#1Clare B. Kelly ('QUB': Queen's University Belfast)H-Index: 2
#2Michelle B. Hookham ('QUB': Queen's University Belfast)H-Index: 5
Last. Timothy J. Lyons ('QUB': Queen's University Belfast)H-Index: 47
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OBJECTIVE This study was conducted to determine the utility of tubular (urinary/plasma neutrophil gelatinase-associated lipocalin [NGAL] and urinary kidney injury molecule 1 [KIM-1]) and glomerular (estimated glomerular filtration rate [eGFR]) biomarkers in predicting preeclampsia (PE) in pregnant women with type 1 diabetes mellitus (T1DM) who were free of microalbuminuria and hypertension at the first trimester. RESEARCH DESIGN AND METHODS This was a prospective study of T1DM pregnancy. Materna...
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#1Baluchnejadmojarad Tourandokht (IUMS: Iran University of Medical Sciences)H-Index: 26
#2Hossein Zeinali (IUMS: Iran University of Medical Sciences)H-Index: 3
Last. Mehrdad Roghani (Shahed University)H-Index: 26
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Abstract Inflammation is a common hallmark of neurodegenerative disorders. Systemic inflammation is usually associated with cognitive deficits. Scutellarin is a flavone with established antioxidant, anti-inflammatory, and neuroprotective effects. In this study, the effect of this flavone in prevention of lipopolysaccharide (LPS)-induced cognitive deficit was evaluated. LPS was i.p. injected at a dose of 500 μg/kg/day and scutellarin was administered i.p. at doses of 5, 25, or 50 mg/kg/day. Treat...
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#1Margot EggerH-Index: 11
#2Benjamin DieplingerH-Index: 32
Last. T. M. MuellerH-Index: 8
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Abstract Background We assessed the long-term in vitro stability of cardiac troponins and galectin-3 under different storage conditions. Methods We used high-sensitivity cardiac troponin I (hs-cTnI) and galectin-3 assays from Abbott and a high-sensitivity cardiac troponin T (hs-cTnT) assay from Roche. The analyte concentrations of 30 patients were measured in heparin-treated plasma, EDTA-treated plasma and serum samples after the following storage conditions: 1) samples used immediately after bl...
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#1Piotr CzubkowskiH-Index: 9
#2Aldona WierzbickaH-Index: 14
Last. Piotr SochaH-Index: 31
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PURPOSE:In adult liver transplant recipients, coronary artery disease and congestive heart failure are significant cause of morbidity and mortality. This may be attributed to the long-term immunosuppressive treatment, mostly with calcineurin inhibitors and steroids, which in long-term may be associated with hyperlipidemia, oxidative stress and cardiovascular complications. Since such data for children is sparse, the aim of this study was to assess the lipid and oxidative stress markers after ped...
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#1Yan LiuH-Index: 1
#2Baoxin Shi (Tianjin Medical University)H-Index: 1
Last. Hui ZhangH-Index: 1
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: BACKGROUND The acceptances and long-term outcomes of the renal transplantations are seriously jeopardized by inflammatory responses and damage to tissues. The present study intended to explicate the pharmacological effect of luteolin (LT) in renal ischemia/reperfusion (I/R) injury and the possible mechanism of action of LT. MATERIAL AND METHODS The effect of LT on the level of interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α in the homogenates of kidney tissues of male Swiss albino...
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Cited By3
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Fluoride is an environmental contaminant that is ubiquitously present in air, water, and soil. It is commonly added in minute quantity to drinking water, toothpaste, and mouth rinses to prevent tooth decay. Epidemiological findings have demonstrated that exposure to fluoride induced neurodevelopmental toxicity, developmental neurotoxicity, and motor disorders. The neuroprotective effect of clofibrate, a peroxisome proliferator-activated receptor alpha agonist, was investigated in the present stu...
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#2Zhengkai Wei (FOSU: Foshan University)H-Index: 1
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Abstract In recent years, numerous studies paid more attention to the molecular mechanisms associated with fluoride toxicity. However, the detailed mechanisms of fluoride immunotoxicity in bovine neutrophils remain unclear. Neutrophil extracellular traps (NETs) is a novel immune mechanism of neutrophils. We hypothesized that sodium fluoride (NaF) can trigger NETs activation and release, and investigate the related molecular mechanisms during the process. We exposed peripheral blood neutrophils t...
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#1Beata Olas (Hong Kong Environmental Protection Department)H-Index: 1
Honey is a sweet, viscous syrup produced by the honey bee (Apis mellifera). It is probably the first natural sweetener ever discovered, and is currently used as a nutritious food supplement and medicinal agent. The aim of the present mini-review is to summarize and update the current knowledge regarding the role of honey in CVDs based on various experimental models. It also describes the role of its phenolic compounds in treating CVDs. Many such phenolic and flavonoid compounds, including querce...
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Abstract Cobalt (Co) intoxication arising from occupational exposures and ion release from metal implants has been associated with neurological alterations such as cognitive decline, incoordination and depression. The present study evaluated the mechanisms of neuro-protection exerted by Luteolin (Lut; 100 mg/kg) and Gallic acid (GA; 120 mg/kg) in Wistar rats exposed to cobalt chloride (CoCl2) at 150 mg/kg for 7 consecutive days. Results indicate that CoCl2 induced neuro-behavioural deficits spec...
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In this study, several lines of evidence are provided to show that Na + , K + -ATPase activity exerts vital roles in normal brain development and function and that loss of enzyme activity is implicated in neurodevelopmental, neuropsychiatric and neurodegenerative disorders, as well as increased risk of cancer, metabolic, pulmonary and cardiovascular disease. Evidence is presented to show that fluoride (F) inhibits Na + , K + -ATPase activity by altering biological pathways through modifying the ...
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