Match!

Is high vitamin B12 status a cause of lung cancer

Published on Sep 15, 2019in International Journal of Cancer4.982
· DOI :10.1002/IJC.32033
Anouar Fanidi4
Estimated H-index: 4
(University of Cambridge),
Robert Carreras-Torres9
Estimated H-index: 9
(IARC: International Agency for Research on Cancer)
+ 53 AuthorsPaul Brennan87
Estimated H-index: 87
(IARC: International Agency for Research on Cancer)
Sources
Abstract
Vitamin B supplementation can have side effects for human health, including cancer risk. We aimed to elucidate the role of vitamin B12 in lung cancer etiology via direct measurements of pre-diagnostic circulating vitamin B12 concentrations in a nested case–control study, complemented with a Mendelian randomization (MR) approach in an independent case–control sample. We used pre-diagnostic biomarker data from 5183 case–control pairs nested within 20 prospective cohorts, and genetic data from 29,266 cases and 56,450 controls. Exposures included directly measured circulating vitamin B12 in pre-diagnostic blood samples from the nested case–control study, and 8 single nucleotide polymorphisms associated with vitamin B12 concentrations in the MR study. Our main outcome of interest was increased risk for lung cancer, overall and by histological subtype, per increase in circulating vitamin B12 concentrations. We found circulating vitamin B12 to be positively associated with overall lung cancer risk in a dose response fashion (odds ratio for a doubling in B12 [OR log2B12 ] = 1.15, 95% confidence interval (95%CI) = 1.06–1.25). The MR analysis based on 8 genetic variants also indicated that genetically determined higher vitamin B12 concentrations were positively associated with overall lung cancer risk (OR per 150 pmol/L standard deviation increase in B12 [OR SD ] = 1.08, 95%CI = 1.00–1.16). Considering the consistency of these two independent and complementary analyses, these findings support the hypothesis that high vitamin B12 status increases the risk of lung cancer. © 2018 International Agency for Research on Cancer (IARC/WHO); licensed by UICC
  • References (18)
  • Citations (5)
📖 Papers frequently viewed together
35 Citations
9 Authors (Anouar Fanidi, ..., Paul Brennan)
36 Authors (Hui Zuo, ..., Arve Ulvik)
6 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References18
Newest
#1Yumie Takata (Vandy: Vanderbilt University)H-Index: 11
#2Xiao-Ou Shu (Vandy: Vanderbilt University)H-Index: 102
Last. Qiuyin Cai (Vandy: Vanderbilt University)H-Index: 69
view all 9 authors...
Purpose We prospectively examined associations of lung cancer risk with food intake of B vitamins involved in one-carbon metabolism and the use of folic acid-containing supplements among a low-income population of black and white adults in the Southeastern US.
1 CitationsSource
#1Xiang Li (Guangzhou Medical University)H-Index: 4
#2Na Li (Guangzhou Medical University)H-Index: 2
Last. Justin Jong-Leong Wong (USYD: University of Sydney)H-Index: 2
view all 13 authors...
Ammonium tetrathiomolybdate (ATTM) has been used in breast cancer therapy for copper chelation, as elevated copper promotes tumor growth. ATTM is also an identified H2S donor and endogenous H2S facilitates VitB12-induced S-adenosylmethionine (SAM) generation, which have been confirmed in m6A methylation and lung cancer development. The m6A modification was recently shown to participate in lung adenocarcinoma (LUAD) progression. These conflicting analyses of ATTM’s anticancer versus H2S’s carcino...
2 CitationsSource
#1Geoffrey UrbanskiH-Index: 3
#1Geoffrey UrbanskiH-Index: 5
Last. V. LacombeH-Index: 1
view all 9 authors...
The association between elevated plasma vitamin B12 (B12) level and solid cancers has been documented by two national registries. However, their design did not allow for the adjustment for other conditions associated with elevated B12. The objectives of this study were to confirm this association after the adjustment for all causes of elevated B12, and to study the variations according to the increasing B12 level, the type of cancers, and the presence of metastases. We compared 785 patients with...
2 CitationsSource
#1Daniela Mariosa (IARC: International Agency for Research on Cancer)H-Index: 2
#2Robert Carreras-Torres (IARC: International Agency for Research on Cancer)H-Index: 9
Last. Paul Brennan (IARC: International Agency for Research on Cancer)H-Index: 87
view all 5 authors...
4 CitationsSource
#1Anouar Fanidi (IARC: International Agency for Research on Cancer)H-Index: 9
#2David C. Muller (Imperial College London)H-Index: 20
Last. Mattias Johansson (Harvard University)H-Index: 14
view all 58 authors...
Background: Circulating concentrations of B vitamins and factors related to one-carbon metabolism have been found to be strongly inversely associated with lung cancer risk in the European Prospecti ...
15 CitationsSource
#1Theodore M. BraskyH-Index: 19
#2Emily WhiteH-Index: 62
Last. Chi-Ling ChenH-Index: 2
view all 3 authors...
PurposeInconsistent findings have been reported of a link between the use of one-carbon metabolism–related B vitamins and lung cancer risk. Because of the high prevalence of supplemental vitamin B use, any possible increased association warrants further investigation. We examined the association between long-term use of supplemental B vitamins on the one-carbon metabolism pathway and lung cancer risk in the Vitamins and Lifestyle (VITAL) cohort, which was designed specifically to look at supplem...
30 CitationsSource
#1James McKay (IARC: International Agency for Research on Cancer)H-Index: 51
#2Rayjean J. Hung (Lunenfeld-Tanenbaum Research Institute)H-Index: 50
Last. Christopher I. Amos (Dartmouth College)H-Index: 104
view all 140 authors...
Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genome-wide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibility loci achieving genome-wide significance, including 10 new loci. The new loci highlight the striki...
132 CitationsSource
#1Jack Bowden (UoB: University of Bristol)H-Index: 35
#2Fabiola Del Greco MH-Index: 11
Last. John R. Thompson (University of Leicester)H-Index: 68
view all 6 authors...
Background: : MR-Egger regression has recently been proposed as a method for Mendelian randomization (MR) analyses incorporating summary data estimates of causal effect from multiple individual variants, which is robust to invalid instruments. It can be used to test for directional pleiotropy and provides an estimate of the causal effect adjusted for its presence. MR-Egger regression provides a useful additional sensitivity analysis to the standard inverse variance weighted (IVW) approach that a...
224 CitationsSource
#1George Davey-Smith (UoB: University of Bristol)H-Index: 30
#1George Davey Smith (UoB: University of Bristol)H-Index: 182
Last. Gibran Hemani (UoB: University of Bristol)H-Index: 37
view all 2 authors...
Observational epidemiological studies are prone to confounding, reverse causation and various biases and have generated findings that have proved to be unreliable indicators of the causal effects of modifiable exposures on disease outcomes. Mendelian randomization (MR) is a method that utilizes genetic variants that are robustly associated with such modifiable exposures to generate more reliable evidence regarding which interventions should produce health benefits. The approach is being widely a...
691 CitationsSource
#1Stephen Burgess (University of Cambridge)H-Index: 48
#2Adam S. Butterworth (University of Cambridge)H-Index: 51
Last. Simon G. Thompson (University of Cambridge)H-Index: 76
view all 3 authors...
Genome-wide association studies, which typically report regression coefficients summarizing the associations of many genetic variants with various traits, are potentially a powerful source of data for Mendelian randomization investigations. We demonstrate how such coefficients from multiple variants can be combined in a Mendelian randomization analysis to estimate the causal effect of a risk factor on an outcome. The bias and efficiency of estimates based on summarized data are compared to those...
570 CitationsSource
Cited By5
Newest
#1Yumie Takata (Vandy: Vanderbilt University)H-Index: 11
#2Xiao-Ou Shu (Vandy: Vanderbilt University)H-Index: 102
Last. Qiuyin Cai (Vandy: Vanderbilt University)H-Index: 69
view all 9 authors...
Purpose We prospectively examined associations of lung cancer risk with food intake of B vitamins involved in one-carbon metabolism and the use of folic acid-containing supplements among a low-income population of black and white adults in the Southeastern US.
1 CitationsSource
#1Xiang Li (Guangzhou Medical University)H-Index: 4
#2Na Li (Guangzhou Medical University)H-Index: 2
Last. Justin Jong-Leong Wong (USYD: University of Sydney)H-Index: 2
view all 13 authors...
Ammonium tetrathiomolybdate (ATTM) has been used in breast cancer therapy for copper chelation, as elevated copper promotes tumor growth. ATTM is also an identified H2S donor and endogenous H2S facilitates VitB12-induced S-adenosylmethionine (SAM) generation, which have been confirmed in m6A methylation and lung cancer development. The m6A modification was recently shown to participate in lung adenocarcinoma (LUAD) progression. These conflicting analyses of ATTM’s anticancer versus H2S’s carcino...
2 CitationsSource
#1Geoffrey UrbanskiH-Index: 3
#1Geoffrey UrbanskiH-Index: 5
Last. V. LacombeH-Index: 1
view all 9 authors...
The association between elevated plasma vitamin B12 (B12) level and solid cancers has been documented by two national registries. However, their design did not allow for the adjustment for other conditions associated with elevated B12. The objectives of this study were to confirm this association after the adjustment for all causes of elevated B12, and to study the variations according to the increasing B12 level, the type of cancers, and the presence of metastases. We compared 785 patients with...
2 CitationsSource
#1Theodore M. Brasky (OSU: Ohio State University)H-Index: 19
#2Roberta M. Ray (Fred Hutchinson Cancer Research Center)H-Index: 32
Last. Marian L. Neuhouser (Fred Hutchinson Cancer Research Center)H-Index: 65
view all 6 authors...
We and others have reported associations between B vitamins principally involved in one-carbon metabolism and increased lung cancer risk; however, results for women have been inconsistent. Here we report on the association of supplemental vitamins B6 , folic acid and B12 intake and lung cancer risk using data from the Women's Health Initiative (WHI) study of postmenopausal women. Between 1993 and 1998, 161,808 women were recruited to participate in the WHI at 40 clinical centers in the US. After...
Source
#1Daniela Mariosa (IARC: International Agency for Research on Cancer)H-Index: 2
#2Robert Carreras-Torres (IARC: International Agency for Research on Cancer)H-Index: 9
Last. Paul Brennan (IARC: International Agency for Research on Cancer)H-Index: 87
view all 5 authors...
4 CitationsSource