Match!

Is high vitamin B12 status a cause of lung cancer

Published on Sep 15, 2019in International Journal of Cancer4.98
· DOI :10.1002/ijc.32033
Anouar Fanidi2
Estimated H-index: 2
(University of Cambridge),
Robert Carreras-Torres7
Estimated H-index: 7
(IARC: International Agency for Research on Cancer)
+ 53 AuthorsPaul Brennan94
Estimated H-index: 94
(IARC: International Agency for Research on Cancer)
View in Source
Abstract
Vitamin B supplementation can have side effects for human health, including cancer risk. We aimed to elucidate the role of vitamin B12 in lung cancer etiology via direct measurements of pre-diagnostic circulating vitamin B12 concentrations in a nested case–control study, complemented with a Mendelian randomization (MR) approach in an independent case–control sample. We used pre-diagnostic biomarker data from 5183 case–control pairs nested within 20 prospective cohorts, and genetic data from 29,266 cases and 56,450 controls. Exposures included directly measured circulating vitamin B12 in pre-diagnostic blood samples from the nested case–control study, and 8 single nucleotide polymorphisms associated with vitamin B12 concentrations in the MR study. Our main outcome of interest was increased risk for lung cancer, overall and by histological subtype, per increase in circulating vitamin B12 concentrations. We found circulating vitamin B12 to be positively associated with overall lung cancer risk in a dose response fashion (odds ratio for a doubling in B12 [OR log2B12 ] = 1.15, 95% confidence interval (95%CI) = 1.06–1.25). The MR analysis based on 8 genetic variants also indicated that genetically determined higher vitamin B12 concentrations were positively associated with overall lung cancer risk (OR per 150 pmol/L standard deviation increase in B12 [OR SD ] = 1.08, 95%CI = 1.00–1.16). Considering the consistency of these two independent and complementary analyses, these findings support the hypothesis that high vitamin B12 status increases the risk of lung cancer. © 2018 International Agency for Research on Cancer (IARC/WHO); licensed by UICC
  • References (14)
  • Citations (2)
References14
Newest
#1Anouar Fanidi (IARC: International Agency for Research on Cancer)H-Index: 9
#2David C. Muller (Imperial College London)H-Index: 17
Last.Mattias Johansson (Harvard University)H-Index: 14
view all 58 authors...
13 CitationsSource
#1Theodore M. BraskyH-Index: 17
#2Emily WhiteH-Index: 65
Last.Chi-Ling ChenH-Index: 2
view all 3 authors...
23 CitationsSource
#1James D. McKay (IARC: International Agency for Research on Cancer)H-Index: 51
#2Rayjean J. Hung (U of T: University of Toronto)H-Index: 46
Last.Christopher I. Amos (Dartmouth College)H-Index: 101
view all 140 authors...
92 CitationsSource
#1Jack Bowden (UoB: University of Bristol)H-Index: 29
#2Fabiola Del Greco MH-Index: 20
Last.John R. Thompson (University of Leicester)H-Index: 65
view all 6 authors...
153 CitationsSource
#1George Davey-Smith (UoB: University of Bristol)H-Index: 189
#2Gibran Hemani (UoB: University of Bristol)H-Index: 33
566 CitationsSource
#1Stephen Burgess (University of Cambridge)H-Index: 43
#2Adam S. Butterworth (University of Cambridge)H-Index: 46
Last.Simon G. Thompson (University of Cambridge)H-Index: 102
view all 3 authors...
422 CitationsSource
#1Niels Grarup (UCPH: University of Copenhagen)H-Index: 55
#2Patrick Sulem (deCODE genetics)H-Index: 66
Last.Oluf PedersenH-Index: 108
view all 30 authors...
52 CitationsSource
#1Mattias JohanssonH-Index: 37
#2Caroline L. ReltonH-Index: 49
Last.Paul BrennanH-Index: 8
view all 45 authors...
107 CitationsSource
#1Marta Ebbing (Haukeland University Hospital)H-Index: 16
#2Kaare H. Bønaa (Haukeland University Hospital)H-Index: 48
Last.Stein Emil VollsetH-Index: 94
view all 13 authors...
277 CitationsSource
#1Øivind MidttunH-Index: 32
#2Steinar Hustad (University of Bergen)H-Index: 23
Last.Per Magne Ueland (University of Bergen)H-Index: 87
view all 3 authors...
192 CitationsSource
Cited By2
Newest
#1Daniela Mariosa (IARC: International Agency for Research on Cancer)H-Index: 1
#2Robert Carreras-Torres (IARC: International Agency for Research on Cancer)H-Index: 7
Last.Paul Brennan (IARC: International Agency for Research on Cancer)H-Index: 94
view all 5 authors...
Source
#1Yumie Takata (Vandy: Vanderbilt University)H-Index: 9
#2Xiao-Ou Shu (Vandy: Vanderbilt University)H-Index: 100
Last.Qiuyin Cai (Vandy: Vanderbilt University)H-Index: 66
view all 9 authors...
Source
View next paperVitamin D and Lung Cancer Risk: A Comprehensive Review and Meta-Analysis