Obesity and brain volume loss in multiple sclerosis

Pathologically, multiple sclerosis (MS) is characterized by inflammation and neurodegeneration; the latter is the substrate of loss of brain volume, detectable by serial MRI. Clinically, MS is often characterized by progressive cognitive and physical impairment, and these impairments are associated with changes in brain volume. The accessibility of brain volume measurement and ability to determine change over relatively short periods make it a...