Cardiovascular and mortality events in type 2 diabetes cardiovascular outcomes trials: a systematic review with trend analysis

Published on Mar 1, 2019in Acta Diabetologica2.996
· DOI :10.1007/s00592-018-1253-5
Lorenzo M. Vetrone1
Estimated H-index: 1
(Leicester General Hospital),
Francesco Zaccardi24
Estimated H-index: 24
(Leicester General Hospital)
+ 5 AuthorsKamlesh Khunti66
Estimated H-index: 66
(Leicester General Hospital)
Aims To investigate cardiovascular disease and mortality trends in control arm participants of diabetes cardiovascular outcome trials (CVOTs).
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  • Citations (2)
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Direct oral anticoagulants (DOACs) include dabigatran, which inhibits thrombin, and apixaban, edoxaban, and rivaroxaban, which inhibit factor Xa. They have been extensively studied in large trials involving patients affected by the most common cardiovascular diseases. As the presence of diabetes leads to peculiar changes in primary and secondary hemostasis, in this review we highlight the current evidence regarding DOAC use in diabetic patients included in the majority of recently conducted stud...
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