Ratios of proteins in cerebrospinal fluid in Parkinson's disease cognitive decline: prospective study

Background : There is a need for biomarkers of dementia in PD. Objectives : To determine if the levels of the main CSF proteins and their ratios are associated with deterioration in cognition and progression to dementia in the short to mid term. Methods : The Parkinson's Progression Markers Initiative database was used as an exploratory cohort, and a center‐based cohort was used as a replication cohort. Amyloid ß1‐42, total tau, threonine‐181...