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Evidence of Human Milk Oligosaccharides in maternal circulation already during pregnancy - a pilot study

Published on Mar 1, 2019in American Journal of Physiology-endocrinology and Metabolism4.125
· DOI :10.1152/ajpendo.00320.2018
Evelyn Jantscher-Krenn7
Estimated H-index: 7
(Medical University of Graz),
Johanna Aigner1
Estimated H-index: 1
(Medical University of Graz)
+ 5 AuthorsMireille N. M. van Poppel39
Estimated H-index: 39
(University of Graz)
Abstract
Human milk oligosaccharides (HMOs) are bioactive glycans linked with health benefits to both the breast-fed infant and lactating mother. We hypothesized that HMOs are present before lactation, alre...
  • References (44)
  • Citations (5)
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References44
Newest
#1Tadasu Urashima (Obihiro University of Agriculture and Veterinary Medicine)H-Index: 30
#2Jun Hirabayashi (AIST: National Institute of Advanced Industrial Science and Technology)H-Index: 41
Last. Akira KobataH-Index: 68
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16 CitationsSource
#1Ann E. Lin (UCSD: University of California, San Diego)H-Index: 5
#2Chloe A. Autran (UCSD: University of California, San Diego)H-Index: 12
Last. Lars Bode (UCSD: University of California, San Diego)H-Index: 30
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Streptococcus agalactiae (group B Streptococcus, GBS) is a leading cause of invasive bacterial infections in newborns, typically acquired vertically during childbirth secondary to maternal vaginal colonization. Human milk oligosaccharides (HMOs) have important nutritional and biological activities that guide the development of the immune system of the infant and shape the composition of normal gut microbiota. In this manner, HMOs help protect against pathogen colonization and reduce the risk of ...
26 CitationsSource
ABSTRACTObjectives:Human milk oligosaccharides (HMOs) are considered to play an important role for the infant. As the biotechnical production of some HMOs is feasible today and clinical studies are being designed, the individual variation of the total amount of HMOs and of single components is of pa
36 CitationsSource
#1Michelle K. McGuireH-Index: 25
#2Courtney L. Meehan (WSU: Washington State University)H-Index: 10
Last. Lars Bode (UCSD: University of California, San Diego)H-Index: 30
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Background: Human milk is a complex fluid comprised of myriad substances, with one of the most abundant substances being a group of complex carbohydrates referred to as human milk oligosaccharides (HMOs). There has been some evidence that HMO profiles differ in populations, but few studies have rigorously explored this variability. Objectives: We tested the hypothesis that HMO profiles differ in diverse populations of healthy women. Next, we examined relations between HMO and maternal anthropome...
54 CitationsSource
#1Norbert Sprenger (Nestlé)H-Index: 19
#2Le Ye Lee (NUS: National University of Singapore)H-Index: 4
Last. Sagar K. Thakkar (Nestlé)H-Index: 17
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Background Human milk is the recommended and sole nutrient source for newborns. One of the largest components of human milk is oligosaccharides (HMOs) with major constituents determined by the mother genotype for the fucosyltransferase 2 (FUT2, secretor) gene. HMO variation has been related with infant microbiota establishment, diarrhea incidence, morbidity and mortality, IgE associated eczema and body composition. Objectives We investigated the (i) dependence of several major representative HMO...
26 CitationsSource
#1Gege XuH-Index: 9
Last. Carlito B. LebrillaH-Index: 73
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38 CitationsSource
#1Anna Kulinich (NAU: Nanjing Agricultural University)H-Index: 4
#2Li Liu (NAU: Nanjing Agricultural University)H-Index: 12
Abstract In order to secure the health of newborns over the period of immune immaturity during the first months of life, a mother provides her offspring with passive protection: bioactive molecules transferred through the placenta and breast milk. It is well known that human milk contains immunoglobulins (Ig), immune cells and diverse cytokines, which affect newborn directly or indirectly and contribute to the maturation of the immune system. However, in addition to the above-stated molecules, h...
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#1Sharon M. DonovanH-Index: 44
#2Sarah S. Comstock (MSU: Michigan State University)H-Index: 15
The immune system of the infant is functionally immature and naive. Human milk contains bioactive proteins, lipids, and carbohydrates that protect the newborn and stimulate innate and adaptive immune
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#1YingYing He (BC: Boston College)H-Index: 3
#2Shubai Liu (Brigham and Women's Hospital)H-Index: 15
Last. David S. Newburg (BC: Boston College)H-Index: 44
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Background A major cause of enteric infection, Gram-negative pathogenic bacteria activate mucosal inflammation through lipopolysaccharide (LPS) binding to intestinal toll-like receptor 4 (TLR4). Breast feeding lowers risk of disease, and human milk modulates inflammation. Objective This study tested whether human milk oligosaccharides (HMOSs) influence pathogenic Escherichia coli -induced interleukin (IL)-8 release by intestinal epithelial cells (IECs), identified specific proinflammatory signal...
69 CitationsSource
#1Narelle Kennedy (USYD: University of Sydney)H-Index: 2
#2Michael J. Peek (USYD: University of Sydney)H-Index: 18
Last. Ralph Nanan (USYD: University of Sydney)H-Index: 24
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Objective To assess maternal abdominal subcutaneous fat thickness (SFT) measured by ultrasound as an independent predictor of adverse pregnancy outcomes. Design A prospective longitudinal cohort study performed on pregnancies delivered between 2012 and 2014. Setting Sydney, Australia. Population About 1510 pregnant women attending routine obstetric ultrasounds. Methods Maternal SFT was measured on routine ultrasounds at 11–14 weeks’ gestation (SFT1) and 18–22 weeks’ gestation (SFT2). SFT measure...
16 CitationsSource
Cited By5
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#1Magdalena Orczyk-Pawiłowicz (Wrocław Medical University)H-Index: 8
#2Jolanta Lis-Kuberka (Wrocław Medical University)H-Index: 3
Apart from optimal nutritional value, human milk is the feeding strategy to support the immature immunological system of developing newborns and infants. The most beneficial dietary carbohydrate components of breast milk are human milk oligosaccharides (HMOs) and glycoproteins (HMGs), involved in both specific and nonspecific immunity. Fucosylated oligosaccharides represent the largest fraction of human milk oligosaccharides, with the simplest and the most abundant being 2’-fucosyllactose (2ʹFL)...
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#1Ruth Addison (NHS Ayrshire and Arran)
Last. David Tappin (Glas.: University of Glasgow)H-Index: 77
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The WHO recommends exclusive breastfeeding for 6 months, but despite interventions, breastfeeding rates remain stubbornly low. Financial voucher incentives have shown promise but require a biomarker for validation of intake. This study aimed to develop a simple biochemical assay of infant urine that would tell if an infant was receiving any breast milk to validate maternal report. Urine samples were collected and snap frozen from 34 infants attending with minor illness or feeding problems, of wh...
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#1Evelyn Jantscher-Krenn (Medical University of Graz)H-Index: 7
#2Carmen Treichler (Medical University of Graz)H-Index: 1
Last. Mireille N. M. van Poppel (University of Graz)H-Index: 39
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2 CitationsSource
Human milk oligosaccharides have been recognized as an important, functional biomolecule in mothers’ milk. Moreover, these oligosaccharides have been recognized as the third most abundant component of human milk, ranging from 10–15 g/L in mature milk and up to and over 20 g/L reported in colostrum. Initially, health benefits of human milk oligosaccharides were assigned via observational studies on the differences between breastfed and bottle fed infants. Later, pools of milk oligosaccharides wer...
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#1Birgit HirschmuglH-Index: 5
#2Waltraud T. BrandlH-Index: 1
Last. Evelyn Jantscher-KrennH-Index: 7
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Human milk oligosaccharides (HMOs) are present in maternal serum in early gestation, raising the question of whether HMOs can cross the placental barrier and reach fetal circulation. Here, we aimed to detect HMOs in cord blood, and assess HMO composition and concentration in relation to maternal HMOs. In an ex-vivo placental perfusion model, we asked whether HMOs can pass over the placenta. Using HPLC, we measured HMOs in maternal serum and matching venous cord blood samples collected at deliver...
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#1Sarah E Maessen (University of Auckland)H-Index: 1
#2José G. B. Derraik (Uppsala University)H-Index: 24
Last. Wayne S. Cutfield (University of Auckland)H-Index: 42
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#1Zoya GridnevaH-Index: 7
#2Alethea ReaH-Index: 4
Last. Donna T. GeddesH-Index: 23
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Human milk (HM) carbohydrates may affect infant appetite regulation, breastfeeding patterns, and body composition (BC). We investigated relationships between concentrations/calculated daily intakes (CDI) of HM carbohydrates in first year postpartum and maternal/term infant BC, as well as breastfeeding parameters. BC of dyads (n = 20) was determined at 2, 5, 9, and/or 12 months postpartum using ultrasound skinfolds (infants) and bioelectrical impedance spectroscopy (infants/mothers). Breastfeedin...
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#1Manuela-Raluca Pausan (University of Graz)
#2V Kolovetsiou-Kreiner (Medical University of Graz)H-Index: 4
Last. Christine Moissl-Eichinger (University of Graz)H-Index: 22
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Abstract Background Preterm birth is one of the leading causes of neonatal mortality. The causes for spontaneous preterm birth (PTB) are multifactorial and remain often unknown. In this study, we tested the hypothesis that human milk oligosaccharides (HMOs) in blood and urine modulate the maternal urinary and vaginal microbiome and influence the risk for PTB. We analyzed the vaginal and urinary microbiome of a cross-sectional cohort of women with and without preterm labor and correlated our find...
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