Maternally inherited differences within mitochondrial Complex I control murine healthspan.

Pages: 472092
Published: Nov 16, 2018
Abstract
Mitochondrial complex I, the largest enzyme complex of the mitochondrial oxidative phosphorylation machinery, has been proposed to contribute to a variety of age-related pathological alterations as well as longevity. The enzyme complex-consisting proteins are encoded by both nuclear (nDNA) and mitochondrial DNA (mtDNA). While some association studies of mtDNA-encoded complex I genes and lifespan in humans have been reported, experimental...
Paper Details
Title
Maternally inherited differences within mitochondrial Complex I control murine healthspan.
Published Date
Nov 16, 2018
Journal
Pages
472092
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