ANGPTL4 gene E40K variation protects against obesity-associated dyslipidemia in participants with obesity
Abstract
Summary Objective ANGPTL4 inhibits lipoprotein lipase in adipose tissue, regulating plasma triglycerides levels. In persons with obesity plasma ANGPTL4 levels have been positively correlated with body fat mass, TG levels and low HDL. A loss‐of‐function E40K mutation in ANGPTL4 prevents LPL inhibition, resulting in lower TGs and higher HDLc in the general population. Since obesity determines metabolic alterations and consequently is a major risk...
Paper Details
Title
ANGPTL4 gene E40K variation protects against obesity-associated dyslipidemia in participants with obesity
Published Date
Dec 26, 2018
Journal
Volume
5
Issue
1
Pages
83 - 90
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