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Surfactant-Free Direct Access to Porphyrin-Cross-Linked Nanogels for Photodynamic and Photothermal Therapy

Published on Dec 19, 2018in Bioconjugate Chemistry4.349
· DOI :10.1021/acs.bioconjchem.8b00787
Laura Chambre2
Estimated H-index: 2
(Boğaziçi University),
Wen Shang Saw3
Estimated H-index: 3
+ 7 AuthorsAmitav Sanyal25
Estimated H-index: 25
(Boğaziçi University)
Abstract
Photosensitizing nanogels were obtained through a surfactant-free single-step protocol by using a porphyrin-based cross-linker for stabilizing self-assembled nanosized aggregates of thermoresponsive copolymers. Nanogels with varying amounts of porphyrin retained the singlet oxygen generation ability of the porphyrin core and were also capable of inducing temperature increase upon irradiation at 635 nm. Photoinduced killing efficiency was tested against three cell lines: human breast adenocarcinoma (MDA-MB-231 and MCF7) and pancreatic adenocarcinoma (AsPC-1) cells, and a predominant photodynamic mechanism at 450 nm and a mixed photodynamic and photothermal effect at 635 nm was observed. This innovative access to photosensitizing nanogels is a proof of concept, and opens new perspectives toward the preparation of optimized nanophotosensitizers.
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#2David Limón (University of Barcelona)H-Index: 3
Last. Lluïsa Pérez-García (University of Nottingham)H-Index: 20
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Summary Singlet oxygen (SO) is one of the reactive oxygen species that is effective in various uses, including performing chemical reactions, treating water impurities, and aiding in medicinal therapy. The generation of SO is often efficient in solution, although generation from the solid phase in nanomaterials is less reliable. Here, we report the preparation of hybrid supramolecular materials that incorporate a photosensitizer within their nanostructured fibers and demonstrate their high effic...
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#1Bhavya Khurana (Trinity College, Dublin)
#2Piotr Gierlich (UC: University of Coimbra)
Last. Mathias O. Senge (TUM: Technische Universität München)H-Index: 42
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Photodynamic therapy (PDT), a shining beacon in the realm of photomedicine, is a non-invasive technique that utilizes dye-based photosensitizers (PSs) in conjunction with light and oxygen to produce reactive oxygen species to combat malignant tissues and infectious microorganisms. Yet, for PDT to become a common, routine therapy, it is still necessary to overcome limitations such as photosensitizer solubility, long-term side effects (e.g., photosensitivity) and to develop safe, biocompatible and...
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