Fibroblast growth factor 21 facilitates peripheral nerve regeneration through suppressing oxidative damage and autophagic cell death

Seeking for effective drugs which are beneficial to facilitating axonal regrowth and elongation after peripheral nerve injury ( PNI ) has gained extensive attention. Fibroblast growth factor 21 ( FGF 21) is a metabolic factor that regulates blood glucose and lipid homeostasis. However, there is little concern for the potential protective effect of FGF 21 on nerve regeneration after PNI and revealing related molecular mechanisms. Here, we firstly...