Genome-wide association study of treatment-resistance in depression and meta-analysis of three independent samples

Background Treatment-resistant depression (TRD) is the most problematic outcome of depression in terms of functional impairment, suicidal thoughts and decline in physical health. Aims To investigate the genetic predictors of TRD using a genome-wide approach to contribute to the development of precision medicine. Method A sample recruited by the European Group for the Study of Resistant Depression (GSRD) including 1148 patients with major...