The RES domain toxins of RES-Xre toxin-antitoxin modules induce cell stasis by degrading NAD+
Abstract
Type II toxin-antitoxin (TA) modules, which are important cellular regulators in prokaryotes, usually encode two proteins, a toxin that inhibits cell growth and a nontoxic and labile inhibitor (antitoxin) that binds to and neutralizes the toxin. Here, we demonstrate that the res-xre locus from Photorhabdus luminescens and other bacterial species function as bona fide TA modules in Escherichia coli. The 2.2 Å crystal structure of the intact...
Paper Details
Title
The RES domain toxins of RES-Xre toxin-antitoxin modules induce cell stasis by degrading NAD+
Published Date
Jan 1, 2019
Journal
Volume
111
Issue
1
Pages
221 - 236
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