Role of Bile Acids and GLP-1 in Mediating the Metabolic Improvements of Bariatric Surgery

Background & aimsBile diversion to the ileum (GB-IL) has strikingly similar metabolic and satiating effects to Roux-en-Y gastric bypass (RYGB) in rodent obesity models. The metabolic benefits of these procedures are thought to be mediated by increased bile acids, although parallel changes in body weight and other confounding variables limit this interpretation.MethodsGlobal G protein–coupled bile acid receptor-1 null (Tgr5−/−) and...