Washing or filtering of blood products does not improve outcome in a rat model of trauma and multiple transfusion

Transfusion is associated with organ failure and nosocomial infection in trauma patients, which may be mediated by soluble bioactive substances in blood products, including extracellular vesicles (EVs). We hypothesize that removing EVs, by washing or filtering of blood products, reduces organ failure and improves host immune response.Blood products were prepared from syngeneic rat blood. EVs were removed from RBCs and platelets by washing....