Assembly of a pan-genome from deep sequencing of 910 humans of African descent

Volume: 51, Issue: 1, Pages: 30 - 35
Published: Jan 1, 2019
Abstract
We used a deeply sequenced dataset of 910 individuals, all of African descent, to construct a set of DNA sequences that is present in these individuals but missing from the reference human genome. We aligned 1.19 trillion reads from the 910 individuals to the reference genome (GRCh38), collected all reads that failed to align, and assembled these reads into contiguous sequences (contigs). We then compared all contigs to one another to identify a...
Paper Details
Title
Assembly of a pan-genome from deep sequencing of 910 humans of African descent
Published Date
Jan 1, 2019
Volume
51
Issue
1
Pages
30 - 35
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