Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis
Abstract
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have become a powerful tool for human disease modeling and therapeutic testing. However, their use remains limited by their immaturity and heterogeneity. To characterize the source of this heterogeneity, we applied complementary single-cell RNA-seq and bulk RNA-seq technologies over time during hiPSC cardiac differentiation and in the adult heart. Using integrated...
Paper Details
Title
Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis
Published Date
Nov 21, 2018
Journal
Volume
9
Issue
1
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