Aseptic loosening after total hip arthroplasty and the risk of cardiovascular disease: A nested case-control study

Patients with surgically treated osteoarthritis of the hip have an increased risk of cardiovascular morbidity and mortality many years after the operation compared with controls. Our hypothesis is that this increased risk after total hip arthroplasty (THA) is mediated by development of periprosthetic osteolysis leading to aseptic loosening of the implant.We conducted a nation-wide, nested, case-control study consisting of patients receiving a...