Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice
Abstract
Cerebral cavernous malformations (CCMs) are common brain vascular dysplasias that are prone to acute and chronic hemorrhage with significant clinical sequelae. The pathogenesis of recurrent bleeding in CCM is incompletely understood. Here, we show that central nervous system hemorrhage in CCMs is associated with locally elevated expression of the anticoagulant endothelial receptors thrombomodulin (TM) and endothelial protein C receptor (EPCR)....
Paper Details
Title
Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice
Published Date
Jan 17, 2019
Journal
Volume
133
Issue
3
Pages
193 - 204
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