Nasal allergen-neutralizing IgG4 antibodies block IgE-mediated responses: Novel biomarker of subcutaneous grass pollen immunotherapy.

Volume: 143, Issue: 3, Pages: 1067 - 1076
Published: Mar 1, 2019
Abstract
Background null Grass pollen subcutaneous immunotherapy (SCIT) is associated with induction of serum IgG4-associated inhibitory antibodies that prevent IgE-facilitated allergen binding to B cells. null Objective null We sought to determine whether SCIT induces nasal allergen-specific IgG4 antibodies with inhibitory activity that correlates closely with clinical response. null Methods null In a cross-sectional controlled study, nasal fluid and...
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Paper Details
Title
Nasal allergen-neutralizing IgG4 antibodies block IgE-mediated responses: Novel biomarker of subcutaneous grass pollen immunotherapy.
Published Date
Mar 1, 2019
Volume
143
Issue
3
Pages
1067 - 1076
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