NDRG2 Regulates Adherens Junction Integrity to Restrict Colitis and Tumorigenesis
Abstract
Objective: Paracellular barriers play an important role in the pathogenesis of IBDs, such as ulcerative colitis (UC) and Crohns disease (CD), and maintain gut homeostasis. N-myc downstream-regulated gene 2 (NDRG2) has been reported to be a tumor suppressor gene and inhibits epithelial-mesenchymal transition (EMT) and colorectal cancer metastasis. However, whether NDRG2 affects colitis initiation and colitis-associated colorectal cancer is...
Paper Details
Title
NDRG2 Regulates Adherens Junction Integrity to Restrict Colitis and Tumorigenesis
Published Date
Dec 29, 2019
Journal
Pages
473397
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