Original paper
Sensitive tumour detection and classification using plasma cell-free DNA methylomes
Abstract
The use of liquid biopsies for cancer detection and management is rapidly gaining prominence1. Current methods for the detection of circulating tumour DNA involve sequencing somatic mutations using cell-free DNA, but the sensitivity of these methods may be low among patients with early-stage cancer given the limited number of recurrent mutations2-5. By contrast, large-scale epigenetic alterations-which are tissue- and cancer-type specific-are...
Paper Details
Title
Sensitive tumour detection and classification using plasma cell-free DNA methylomes
Published Date
Nov 1, 2018
Journal
Volume
563
Issue
7732
Pages
579 - 583
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Notes
History