Multi-color single molecule imaging uncovers extensive heterogeneity in mRNA decoding
Abstract
mRNA translation is a key step in decoding genetic information. Genetic decoding is surprisingly heterogeneous, as multiple distinct polypeptides can be synthesized from a single mRNA sequence. To study translational heterogeneity, we developed the MoonTag, a new fluorescence labeling system to visualize translation of single mRNAs. When combined with the orthogonal SunTag system, the MoonTag enables dual readouts of translation, greatly...
Paper Details
Title
Multi-color single molecule imaging uncovers extensive heterogeneity in mRNA decoding
Published Date
Nov 24, 2018
Journal
Pages
477661
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