Repurposing CRISPR-Cas12b for mammalian genome engineering
Abstract
The prokaryotic CRISPR-Cas adaptive immune systems provide valuable resources to develop genome editing tools, such as CRISPR-Cas9 and CRISPR-Cas12a/Cpf1. Recently, CRISPR-Cas12b/C2c1, a distinct type V-B system, has been characterized as a dual-RNA-guided DNA endonuclease system. Though being active in vitro, its cleavage activity at endogenous genome remains to be explored. Furthermore, the optimal cleavage temperature of the reported Cas12b...
Paper Details
Title
Repurposing CRISPR-Cas12b for mammalian genome engineering
Published Date
Nov 27, 2018
Journal
Volume
4
Issue
1
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