Escherichia coli “Marionette” strains with 12 highly optimized small-molecule sensors
Abstract
Cellular processes are carried out by many genes, and their study and optimization requires multiple levers by which they can be independently controlled. The most common method is via a genetically encoded sensor that responds to a small molecule. However, these sensors are often suboptimal, exhibiting high background expression and low dynamic range. Further, using multiple sensors in one cell is limited by cross-talk and the taxing of...
Paper Details
Title
Escherichia coli “Marionette” strains with 12 highly optimized small-molecule sensors
Published Date
Nov 26, 2018
Journal
Volume
15
Issue
2
Pages
196 - 204
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