EXTH-70. EFFICIENT DELIVERY OF SIRNAS TO GLIOMA VIA FUNCTIONALIZED EXTRACELLULAR VESICLES PRIMED BY RADIATION

Efficient delivery is a major obstacle in oligonucleotide therapeutics for the treatment of gliomas. Endogenous small vesicles known as extracellular vesicles (EVs) hold potential to act as oligonucleotide delivery vehicles given their unique properties, such as low immunogenicity, innate stability, and ability to cross the blood-brain barrier (BBB). However, their insufficient targeting ability upon intravenous administration limits the...