Thermal stability of single‐domain antibodies estimated by molecular dynamics simulations

Volume: 28, Issue: 2, Pages: 429 - 438
Published: Dec 20, 2018
Abstract
Single-domain antibodies (sdAbs) function like regular antibodies, however, consist of only one domain. Because of their low molecular weight, sdAbs have advantages with respect to production and delivery to their targets and for applications such as antibody drugs and biosensors. Thus, sdAbs with high thermal stability are required. In this work, we chose seven sdAbs, which have a wide range of melting temperature (Tm) values and known...
Paper Details
Title
Thermal stability of single‐domain antibodies estimated by molecular dynamics simulations
Published Date
Dec 20, 2018
Volume
28
Issue
2
Pages
429 - 438
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