Reciprocal negative regulation between the tumor suppressor protein p53 and B cell CLL/lymphoma 6 (BCL6) via control of caspase-1 expression

Volume: 294, Issue: 1, Pages: 299 - 313
Published: Jan 1, 2019
Abstract
Even in the face of physiological DNA damage or expression of the tumor suppressor protein p53, B cell CLL/lymphoma 6 (BCL6) increases proliferation and antagonizes apoptotic responses in B cells. BCL6 represses TP53 transcription and also appears to inactivate p53 at the protein level, and additional findings have suggested negative mutual regulation between BCL6 and p53. Here, using Bcl6−/− knockout mice, HEK293A and HCT116 p53−/− cells, and...
Paper Details
Title
Reciprocal negative regulation between the tumor suppressor protein p53 and B cell CLL/lymphoma 6 (BCL6) via control of caspase-1 expression
Published Date
Jan 1, 2019
Volume
294
Issue
1
Pages
299 - 313
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