Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2
Abstract
An inducible gene expression program is a hallmark of the host inflammatory response. Recently, long intergenic non-coding RNAs (lincRNAs) have been shown to regulate the magnitude, duration, and resolution of these responses. Among these is lincRNA-Cox2, a dynamically regulated gene that broadly controls immune gene expression. To evaluate the in vivo functions of this lincRNA, we characterized multiple models of lincRNA-Cox2-deficient mice....
Paper Details
Title
Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2
Published Date
Nov 1, 2018
Journal
Volume
25
Issue
6
Pages
1511 - 1524.e6
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History