DDIS-13. UNDERSTANDING GLIOBLASTOMA SUSCEPTIBILITY TO TOP2-TARGETING DRUGS FOR PERSONALIZED THERAPY

Poor outcomes in glioblastoma are partially explained by unpredictable individual responses to therapy. Topoisomerase II (TOP2) poisons Etoposide and Doxorubicin, which induce double-strand DNA breaks, are effective for some glioblastoma lines. On the other hand, the TOP2-enzymatic inhibitor MST16 is used for lymphomas, but has not been tested for glioblastoma. We investigated biomarkers for glioblastoma susceptibility to these drugs to...