DDIS-04. COMPOUNDS IDENTIFIED BY STRUCTURE BASED VIRTUAL SCREENING DECREASE GBM BTIC GROWTH AND GLUCOSE UPTAKE

Patient prognosis for individuals diagnosed with GBM remains incredibly poor with a median survival of only 15 months despite aggressive treatment with surgical tumor resection, chemotherapy, and radiation therapy. Therapeutic development to prolong survival has been hampered by a high degree of inter- and intra-tumoral heterogeneity. Contributing to tumor heterogeneity is a subset of highly tumorigenic cells, termed brain tumor initiating cells...