EXTH-71. RADIATION-INDUCED TARGETED NANOPARTICLE-BASED GENE DELIVERY FOR BRAIN TUMORS

Targeted therapy and programmed cell death ligand-1 blockade hold a great promise for the treatment of different aggressive tumor types, however little effect have been observed against gliomas probably due to inability of large antibodies in penetrating the brain. An effective glioma therapy requires a delivery system that reaches tumors in the central nervous system, with limited systemic effect. In this study, we developed an iRGD-based solid...