An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome

eLife7.70
Volume: 8
Published: Mar 5, 2019
Abstract
The age of large-scale genome-wide association studies (GWAS) has provided us with an unprecedented opportunity to evaluate the genetic liability of complex disease using polygenic risk scores (PRS). In this study, we have analysed 162 PRS (p<5×10-05) derived from GWAS and 551 heritable traits from the UK Biobank study (N = 334,398). Findings can be investigated using a web application (http:‌//‌mrcieu.‌mrsoftware.org/‌PRS‌_atlas/), which we...
Paper Details
Title
An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome
Published Date
Mar 5, 2019
Journal
Volume
8
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