Neuron-specific overexpression of core clock genes improves stress-resistance and extends lifespan of Drosophila melanogaster

Volume: 117, Pages: 61 - 71
Published: Mar 1, 2019
Abstract
Gene expression is much altered in aging. We observed age-dependent decline of core clock genes' expression in the whole body of the fruit fly. We hypothesized that inducible overexpression of clock genes (cry, per, tim, cyc and Clk) in the nervous system can improve healthspan of D. melanogaster. We studied the lifespan of transgenic Drosophila and showed life extension for cry, per, cyc and tim genes. It was also the significant positive...
Paper Details
Title
Neuron-specific overexpression of core clock genes improves stress-resistance and extends lifespan of Drosophila melanogaster
Published Date
Mar 1, 2019
Volume
117
Pages
61 - 71
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