Crosslinking dextran electrospun nanofibers via borate chemistry: Proof of concept for wound patches

Dextran-based formulations represent promising candidates for the fabrication of biocompatible scaffolds in tissue engineering or as vehicles for drug delivery. Previous investigations showed that, on its own, dextran is able to promote wound healing in vivo in rat models. Its inherent solubility in water, however, must be overcome by inserting inter-molecular junctions via the use of cross-linkers. While conventional cross-linking methods tend...