Synthesis of Chitosan/Gelatin granule containing amine derivated octa(ammonium chloride) substituted Polyhedral Oligomeric Silsesquioxane and investigating its application as a drug carrier

In this work, we have prepared a new granule hydrogel composites of natural biocompatible polymeric chitosan and gelatin (C-G). The gelatin side groups (hydroxyl and carboxyl) can attach with amine groups of chitosan, which improve the interlink crosslinking in the final nanocomposites. The diameter of the granuls is around 3 mm to 6 mm. Furthermore, in order to reinforce the mechanical properties of granules, for the first time, octa(ammonium...