Design, synthesis and antifungal evaluation of borrelidin derivatives

Volume: 26, Issue: 23-24, Pages: 6035 - 6049
Published: Dec 1, 2018
Abstract
Borrelidin, a nitrile containing 18-membered polyketide macrolide, display potent antifungal activity. In this study, a library of borrelidin derivatives were synthesized. Their structures were elucidated by detailed spectroscopic data analysis. The antifungal activity and cytotoxicity of these target compounds were evaluated by broth microdilution and 3-(4,5-dimethylthiazol-2-yl)-3,5-phenytetrazoliumromide (MTT) methods. Among forty-seven...
Paper Details
Title
Design, synthesis and antifungal evaluation of borrelidin derivatives
Published Date
Dec 1, 2018
Volume
26
Issue
23-24
Pages
6035 - 6049
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