Gut bacterial phospholipase Ds support disease-associated metabolism by generating choline
Abstract
The essential nutrient choline is metabolized by gut bacteria to the disease-associated metabolite trimethylamine (TMA). However, most of the choline obtained via the diet and present in the human body is incorporated into larger metabolites, including the lipid phosphatidylcholine (PC). Here, we report that many choline-utilizing gut microorganisms can hydrolyse PC using a phospholipase D (PLD) enzyme and further convert the released choline to...
Paper Details
Title
Gut bacterial phospholipase Ds support disease-associated metabolism by generating choline
Published Date
Nov 19, 2018
Journal
Volume
4
Issue
1
Pages
155 - 163
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