STIM1 and Orai1 regulate Ca2+ microdomains for activation of transcription

Since calcium (Ca 2+ ) regulates a large variety of cellular signaling processes in a cell's life, precise control of Ca 2+ concentrations within the cell is essential. This enables the transduction of information via Ca 2+ changes in a time-dependent and spatially defined manner. Here, we review molecular and functional aspects of how the store-operated Ca 2+ channel Orai1 creates spatiotemporal Ca 2+ microdomains. The architecture of this...