Marine n−3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer

Published on Jan 3, 2019in The New England Journal of Medicine70.67
· DOI :10.1056/NEJMoa1811403
JoAnn E. Manson240
Estimated H-index: 240
(Harvard University),
Nancy R. Cook108
Estimated H-index: 108
(Harvard University)
+ 14 AuthorsJulie E. Buring163
Estimated H-index: 163
(Harvard University)
Abstract Background Higher intake of marine n−3 (also called omega-3) fatty acids has been associated with reduced risks of cardiovascular disease and cancer in several observational studies. Whether supplementation with n−3 fatty acids has such effects in general populations at usual risk for these end points is unclear. Methods We conducted a randomized, placebo-controlled trial, with a two-by-two factorial design, of vitamin D3 (at a dose of 2000 IU per day) and marine n−3 fatty acids (at a dose of 1 g per day) in the primary prevention of cardiovascular disease and cancer among men 50 years of age or older and women 55 years of age or older in the United States. Primary end points were major cardiovascular events (a composite of myocardial infarction, stroke, or death from cardiovascular causes) and invasive cancer of any type. Secondary end points included individual components of the composite cardiovascular end point, the composite end point plus coronary revascularization (expanded composite of ca...
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