Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis

Volume: 9, Issue: 1
Published: Nov 15, 2018
Abstract
CD8 T cells protect the liver against viral infection, but can also cause severe liver damage that may even lead to organ failure. Given the lack of mechanistic insights and specific treatment options in patients with acute fulminant hepatitis, we develop a mouse model reflecting a severe acute virus-induced CD8 T cell-mediated hepatitis. Here we show that antigen-specific CD8 T cells induce liver damage in a perforin-dependent manner, yet liver...
Paper Details
Title
Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis
Published Date
Nov 15, 2018
Volume
9
Issue
1
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