AGE-ASSOCIATED CHANGES IN SDF-1 TARGETING MIRNAS 29B-1-5P AND 141-3P ARE LINKED TO KYNURENINE LEVELS IN MSCS

We have identified a number of miRNAs that increase with age in human and murine bone marrow-derived mesenchymal stem cells (BMSCs). These miRNAs target a number of osteogenic gene families including the Stromal cell-derived factor-1 (SDF-1α /CXCL12) axis. Two of these SDF-1 targeting miRNAs are also under estrogen suppression: miR-29b-1-5p (normally the 29b-1 passenger strand) and miR-141-3p. Of interest, high levels of kynurenine (KYN), a...