Administration of the benzodiazepine midazolam increases tau phosphorylation in the mouse brain

Volume: 75, Pages: 11 - 24
Published: Mar 1, 2019
Abstract
Preclinical studies have shown that anesthesia might accelerate the clinical progression of Alzheimer's disease (AD) and can have an impact on tau pathology, a hallmark of AD. Although benzodiazepines have been suggested to increase the risk of incident dementia, their impact on tau pathology in vivo is unknown. We thus examined the impact of midazolam, a benzodiazepine that is often administered perioperatively as an anxiolytic, on tau...
Paper Details
Title
Administration of the benzodiazepine midazolam increases tau phosphorylation in the mouse brain
Published Date
Mar 1, 2019
Volume
75
Pages
11 - 24
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