Pharmacophore-based virtual screening for identification of potential selective inhibitors of human histone deacetylase 6

Volume: 77, Pages: 318 - 330
Published: Dec 1, 2018
Abstract
Histone deacetylase (HDAC) 6 plays a role in oncogenic transformation and cancer metastasis via tubulin deacetylation, making it a critical target for anticancer drug design. However, lack of selectivity shown by many of the current HDAC6 inhibitors in clinical use and trials prompts the continuous search for selective inhibitors. Here, 10 pharmacophore hypotheses were developed based on the 3D common features of training set of 20 HDAC...
Paper Details
Title
Pharmacophore-based virtual screening for identification of potential selective inhibitors of human histone deacetylase 6
Published Date
Dec 1, 2018
Volume
77
Pages
318 - 330
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